Journal: NPJ Parkinson's Disease

Article Title: Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities

doi: 10.1038/s41531-022-00343-6

Figure Lengend Snippet: The average PSD spectra of 29 and 20 continuous 5-min LFP recordings from 10 control (blue) and 11 parkinsonian (6-OHDA, red) rats, respectively. The open field test (OFT) reveals a significantly higher peak in the α band (7–10 Hz) in control than in parkinsonian rats in both MC ( a ) and STN ( b ). Meanwhile, there is a lower δ band (1–4 Hz) power in both MC and STN in control than in parkinsonian rats, although the differences are statistically insignificant. In contrast, a peak oscillation in β band (20–40 Hz) in parkinsonian but not in control rats is noted only in MC. PSD spectra were presented as mean (solid curves) ± standard deviation (shaded areas). Data in the bar plots were presented as mean ± standard error of mean (S.E.M.). Data were analyzed with Mann–Whitney U tests. ** p < 0.01, N.S., nonsignificant.

Article Snippet: Magnitude-squared coherence between MC and STN in each frequency band was then computed for LFP coherence analysis ( mscohere function from signal processing toolbox, MATLAB R2018b, MathWorks).

Techniques: Control, Standard Deviation, MANN-WHITNEY

Journal: NPJ Parkinson's Disease

Article Title: Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities

doi: 10.1038/s41531-022-00343-6

Figure Lengend Snippet: a Prokinetic effects of STN-DBS (depolarizing DC currents of −250 to −300μA) were examined in different parameters ( n = 11 rats). b Sample maps of 30-s trajectories in OFT (boxes) and corresponding LFP recordings in MC and STN in a sample parkinsonian rat with baseline free running (including rest and movement), and type 1 and type 2 movements during DBS (Supplementary Movie to ). c Behavioral parameters in matched 30-s video recordings with type 1 and type 2 movements from the same OFT trial in parkinsonian rats. The “baseline” shows the data from sham stimulation in ( a ). n = 5 matched recordings from 3 rats. d Band power analysis according to the behavioral state during STN-DBS. n = 101, 76, and 14 10-s segments from 9 animals for rest, type 1 movement, and type 2 movement, respectively. e Sample sweeps of MU activities in MC from a parkinsonian rat during movement without (baseline) or with STN-DBS. f , g MC MU spike rates ( f , n = 147 matches, i.e. 21 segments × 7 leads, from 7 animals) and STN bursts during STN-DBS ( g , n = 5 matched segments from 4 leads from 2 animals). h , i Average PSD of S(t) ( h ) and the total power of S(t) ( i ) in MC ( n = 37 at rest and n = 24 during movement in baseline, and n = 26 at rest and n = 34 during movement under STN-DBS, from 7 parkinsonian rats). PSD spectra were presented as mean (solid curves) ± standard deviation (shaded areas). Scale bars represent 1 s/500μV. Data in the bar plot were presented as mean ± S.E.M. Data were analyzed with ANCOVA ( a ), Mann–Whitney U tests ( c ), one-way ANOVA following Games–Howell post hoc tests ( d ), 2 × 2 dependent model ANOVA ( f , g ), and 2 × 2 independent model ANOVA ( i ). In ( f ) and ( g ), each horizontal line reports the simple main effect, and each square bracket reports the main effect of baseline vs. DBS in ANOVA. * P < 0.05, ** p < 0.01, *** p < 0.001, N.S., nonsignificant.

Article Snippet: Magnitude-squared coherence between MC and STN in each frequency band was then computed for LFP coherence analysis ( mscohere function from signal processing toolbox, MATLAB R2018b, MathWorks).

Techniques: Standard Deviation, MANN-WHITNEY